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    Legal Status

    Colorado

    Legal

    Last updated November 1, 2025

    This is informational only and does not constitute legal advice. Laws change frequently. Consult qualified legal counsel in Colorado for specific guidance.

    Substance-by-Substance Status

    PsilocybinLegal
    KetamineLegal
    MDMATrials Only
    IbogaineDecriminalized
    AyahuascaDecriminalized

    Policies & Regulations

    Licensing Framework

    ActiveEffective June 2024

    Colorado Natural Medicine Health Act (Proposition 122) legalized psilocybin and psilocin for supervised use at licensed healing centers. The Colorado Department of Regulatory Agencies (DORA) is developing regulations. Personal cultivation and use by adults 21+ is also permitted. DMT, ibogaine, and mescaline (non-peyote) will become regulated in 2026.

    What's Allowed

    • •Licensed healing centers (in development)
    • •Personal cultivation and use of psilocybin/psilocin (adults 21+)
    • •Facilitated sessions at licensed centers (beginning 2025)

    Not Allowed

    • •Commercial sale of psilocybin products
    • •Unlicensed healing centers
    • •Use by individuals under 21

    How to Access

    1. 1.Wait for DORA to finalize healing center licensing (expected early 2025)
    2. 2.Personal cultivation is legal now for adults 21+
    3. 3.Check DORA website for licensed healing center registry when available

    Official Resources

    Colorado DORA — Natural Medicine DivisionProposition 122 Full Text

    Last updated: November 1, 2025

    Recent Changes

    November 1, 2025

    DORA published draft rules for healing center licensing and facilitator training requirements. Public comment period open until January 2026.

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